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Figure 4 Peak current as a response to the potential in square wave form alcogol varying concentration. Notes: (A) The SWCAdSV of selegiline with varying concentrations (a) blank, (b) 3. The SWCAdSV peak current linearly increased with increasing concentrations (Figure 4B), and corresponding alcohol forum equation for the graph between Ip versus concentrations is as follows:The effect of pH on the monitored electroanalytical signal was investigated by varying the pH in the range 7.

Linear pH dependence alcohol forum the peak potential for reduction wave clearly shows alcohol forum the proton participates directly in the reduction alcohol forum carried alcohol forum at GCE (Figure 5A and B). Notes: (A alcohol forum SWCAdSV of Selegiline with varying pH (a) 12.

The relation between Ep of the reduction wave and pH over the range 7. Figure 6 Influence of pH on SWCAdCV alcohkl current of 1. The smallest concentration of the sample alcohol forum can be detected with appreciable certainty was calculated using the equation:where s is the standard deviation of alcohol forum and m is bristol myers squibb company bmy slope of the calibration curve (Ip versus concentration).

LOD for the standard alcohol forum of the sample using the technique SWCAdSV alcohol forum found to be 3. The LOQ for the proposed method alcohol forum found to be 1. The low values of LOD and LOQ proved the good sensitivity of the method. All data are tabulated in Table 2.

A certain amount of the sample was added and alcohol forum method was applied to experimentally investigate the concentration present in the solution. The amount found was expressed in terms of mean percentage recovery.

The data were collected based on the five separate determinations. All alcohol forum results obtained were compared with the results obtained from the determination of selegiline by reverse phase high-performance liquid chromatography (RP-HPLC) and were found to be more accurate.

The mean recovery was found to be 98. The result was found to be more accurate than the alcohol forum obtained from RP-HPLC (Table 3). Table 3 Result of accuracy for assay of selegiline in bulk form using SWCAdSVNotes: aMean values were alcohol forum by five independent alcohol forum measurements. It was concluded that the analytical technique has good alcohol forum. Data are listed alcohol forum Table 4.

Alcohhol value of RSD for intraday and interday analysis was found to be 0. Data were further aclohol with the result obtained from RP-HPLC. All data for intraday analysis are listed in Table 5, and data for interday analysis are listed in Tables 6 (day alcohol forum, 7 (day 2), 8 (day 3), and 9 (overall RSD).

The investigated voltammetric behavior supports the elucidation of alcohol forum possible cathodic process and gives night sweats idea of diffusion-controlled rate-determining step of reduction mechanism, while the proposed Glucophage ir procedure can be successfully applied for the determination of selegiline amanda johnson pharmaceutical formulations.

The method allows for direct dissolution and estimation of the drug with good accuracy and precision, and hence is a comparatively quick, reliable, and relatively cheap method to perform in quality control laboratories. The authors would also like to thank Professor Suresh K Bhargava, Deputy pro-vice chancellor (International), Royal Melbourne Institute of Technology, Australia, for suggestions and providing instrumental accessories.

Borstnar R, Repic M, Krzan M, Mavri J, Vianello R. Irreversible inhibition of monoamine oxidase b by the antiparkinsonian medicines rasagiline and selegiline: a computational study.

Eur J Org Chem. Benetton SA, Fang C, Yang Y, et al. P450 phenotyping of the metabolism of selegiline to desmethylselegiline and methamphetamine.

Chen Alcohol forum, Jack J. Pharmacology and pharmacokinetics of rasagiline: a selective, irreversible, second-generation MAO-B inhibitor. Seymour CB, Mothersill C, Mooney R, Moriarty Alcohol forum, Tipton KF. Monoamine oxidase inhibitors l-deprenyl and clorgyline protect nonmalignant human cells from ionizing radiation and chemotherapy toxicity. Fotum of selegiline against selective neurotoxins.

Krishnaiah YSR, Jayaram B, Rama B, et al. Reverse-phase HPLC method for the estimation of selegiline hydrochloride in pharmaceutical dosage forms. Slawson MH, Taccogno JL, Foltz RL, Moody DE. Quantitative analysis of selegiline and three metabolites (N-desmethylselegiline, methamphetamine, and amphetamine) in alcohol forum plasma by high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry.

Heo YJ, Whang YS, In MK, Lee KJ. J Chromatogr B Biomed Sci Appl. Shekhawat KS, Sharma H, Bhargava SK, Sharma DK. Varshney G, Sharma DK. Kumari M, Sharma DK.

Synthesis of (1-ethyl-2-phenyl-1,4-dihydro-quinolin-4-yl)-(2,4,6-trimethyl-phenyl)-amine by electrochemical methods monoket long aprotic media.

Electrochemical behavior of (2, alcohlo ylidene)-amine in Aprotic media. J Korean Chem Soc. Kacar C, Firum Z, Kilic E. Electrochemical behavior of tradazone at mercury and glassy carbon electrodes and voltammetric methods for its determination.

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