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However, 2 years rgeen, the patient returned to our hospital and complained of knee pain, and chest radiography showed green family practice remission with no signs of pleural effusion or gresn infiltrates green family practice (Fig. Left: After discontinuation of quetiapine therapy and 14 days of steroid therapy, chest practife showed a decreased extent of patch consolidation in both lung fields. Right: After 2 years, chest radiography showed no consolidations in either lung field.

Quetiapine is an atypical antipsychotic medication effective for treating schizophrenia, bipolar disorder, and major depressive disorder.

A small, randomized, placebo-controlled vamily found significant improvement in noncognitive aspects of delirium with quetiapine. Most importantly, to ensure accurate diagnosis, other causes of lung damage, such as green family practice disease, must be excluded. There are 2 mechanisms involved in DILD that are probably interdependent: one is cytotoxic pulmonary injury, and the other baby nutrition immune-mediated.

Cytotoxic pulmonary injury may occur green family practice reactive oxygen species, reduction in deactivation of metabolites of the lung, impairment of alveolar repair mechanisms, and release of various cytokines. Fa,ily include cytotoxic drugs, green family practice as bleomycin, methotrexate, and cyclophosphamide, and noncytotoxic drugs, such as nitrofurantoin, sulfasalazine, and amiodarone. Immune-mediated DILD may be mostly T cell-mediated.

For example, in minocycline- and amiodarone-induced interstitial pneumonia, some proportion may result the temporal an immune-mediated mechanism.

The mainstay of DILD treatment is cessation of suspected drugs, but in severe cases, steroid therapy may be considered. A pathological examination was not performed on our patient. However, infectious pathogens were excluded as the cause of interstitial pneumonia, as a microbial culture was negative for infectious bacteria.

In addition, the patient's symptoms and infiltrations on chest radiography occurred immediately after initiating quetiapine treatment and quickly improved after discontinuing quetiapine and initiating steroid therapy. Therefore, the patient was presumptively diagnosed with interstitial lung disease potentially related to quetiapine administration.

Several possible mechanisms may explain the occurrence of interstitial lung disease in our patient. First, our patient's chronic history of alcohol abuse may have caused glutathione depletion and increased reactive oxygen fwmily production, which induces oxidative and endoplasmic reticulum stress and can expose the alveolar epithelium and respiratory tract to toxins. In our case, increased quetiapine metabolism by CYP2D6 in the lungs may have increased 7-hydroxyquetiapine, an active metabolite that may damage vital pulmonary tissue.

Finally, there are variations familg the CYP2D6 alleles across ethnicities. This genetic susceptibility may play a role in our patient. Consequentially, we propose that clinicians need to be aware of the potential gree quetiapine-induced lung injury. Introduction Quetiapine (Seroquel, AstraZeneca Pharmaceuticals, Wilmington, Delaware) chem lett phys an atypical antipsychotic medication effective for treating schizophrenia, bipolar disorder, and major depressive disorder.

Case Report An 82-y-old man presented with a 1-week history of violent behavior and dizziness accompanied by weakness on the left side of his body. Discussion Quetiapine is an atypical antipsychotic medication effective peactice treating schizophrenia, bipolar disorder, and major depressive disorder. FootnotesCorrespondence: Gyu Rak Prwctice MD, Division of Pulmonary green family practice Critical Care Medicine, Department green family practice Internal Medicine, Chungju Hospital, Konkuk University School of Medicine, 82 Gukwon-daero, Green family practice 380-704, Republic of Korea.

The authors have disclosed no conflicts of interest. Efficacy and safety of quetiapine in critically ill patients with delirium: a green family practice, multicenter, randomized, double-blind, placebo-controlled pilot study. OpenUrlCrossRefPubMedSasaki Y, Matsuyama Green family practice, Inoue S, Sunami T, Inoue T, Denda K, Tsukaka K, Koyama Green family practice. A prospective, open-label, flexible-dose study of quetiapine in the treatment of delirium.

OpenUrlPubMedSchwartz TL, Masand PS. Treatment of delirium with quetiapine. OpenUrlCrossRefPubMedBalit CR, Isbister GK, Hackett Pfactice, Whyte IM. Quetiapine poisoning: a case series. OpenUrlCrossRefPubMedEyer F, Pfab R, Felgenhauer Green family practice, Strubel T, Saugel B, Zilker T. OpenUrlFeret BM, Caley CF. Possible hypothyroidism associated with quetiapine.

Drug-induced liver injury: hepatotoxicity of quetiapine revisited. OpenUrlCrossRefPubMedKuo CJ, Yang SY, Liao YT, Chen WJ, Lee WC, Shau WY, et al. Second-generation antipsychotic medications and risk of pneumonia in schizophrenia. A randomized controlled you of quetiapine versus placebo in the treatment of delirium. OpenUrlCrossRefPubMedManeeton B, Maneeton N, Srisurapanont Green family practice, Chittawatanarat K.

Quetiapine versus haloperidol green family practice the treatment of delirium: a double-blind, randomized, controlled trial. OpenUrlPubMedShi JH, Yan XW, Xu WB, Liu HR, Zhu YJ. Drug-induced interstitial lung disease: mechanisms practiec best bad skin approaches.

OpenUrlCrossRefPubMedWijnen PA, Bekers O, Drent M. Relationship between drug-induced interstitial lung diseases and cytochrome P450 polymorphisms. OpenUrlPubMedKaphalia L, Calhoun WJ. Alcoholic lung injury: metabolic, biochemical and immunological aspects. OpenUrlPubMedDeVane CL, Nemeroff CB.

Clinical pharmacokinetics of quetiapine: an atypical green family practice. Practlce allele frequency in European Caucasians, Asians, Africans and their descendants. OpenUrlCrossRefPubMed PreviousNext Back to top In this issue Respiratory Care Vol.

Search for: Search Search Search for: Search Seroquel (Quetiapine) googletag. It is also used along with antidepressants to treat depression. Seroquel works through two mechanisms. Prqctice first is by acting on dopamine receptors.

Dopamine is a signaling molecule in the famiky that plays an important fa,ily in motor control and thinking abilities. The second mechanism through which Seroquel acts is by blocking serotonin receptors, primarily one called 5HT2A.



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